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Effect of Metformin and Pioglitazone on Treatment of Psoriasis

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Management number 233443634 Release Date 2026/06/27 List Price $13.45 Model Number 233443634
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Psoriasis vulgaris is a common, chronic, relapsing skin disease characterized by predominant involvement of skin, nails and joints. Recent advances in its pathophysiology have shifted the notion of psoriasis from that of a 'disease of the skin' to a 'T-cell mediated systemic disease'. Metformin acts as a modulator of the immune system, in psoriatic patients and has a remarkable effect on the early stages of psoriasis. The activation of PPAR-γ by pioglitazone results in a reduction of the formation of the proinflammatory cytokines, and the inflammatory cells infiltration. These findings support the potential use of PPAR-γ ligands as therapeutic agents in the therapy of conditions associated with autoimmune disease. Read more

ISBN10 3330029455
ISBN13 978-3330029453
Language English
Publisher LAP LAMBERT Academic Publishing
Dimensions 5.91 x 0.13 x 8.66 inches
Item Weight 3.17 ounces
Print length 56 pages
Publication date January 13, 2017

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