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Trifexis Heartworm Prevention | Treats & Controls Flea Infestations + 4 Other Worms | Dogs 20.1-40 lbs.

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Product details

Management number 238309991 Release Date 2026/07/11 List Price $66.52 Model Number 238309991
Category

Get fast-acting parasite protection for your dog in just one tablet every month. Trifexis not only prevents heartworm disease in dogs, but also treats and controls intestinal worms including roundworms, whipworms and hookworms. Trifexis also delivers fast-acting flea treatment and flea infestation prevention, starting to kill fleas within 30 minutes of application and killing 100% of fleas on your dog within just 4 hours. It’s no surprise why Trifexis has been protecting dogs from parasites for nearly 10 years with more than 272 million doses distributed.* When untreated, intestinal worms and fleas can cause serious symptoms and major discomfort for your dog. Intestinal worms are common parasites – even for indoor dogs – and can cause vomiting, weight loss and diarrhea. And flea bites aren’t just painful, they can cause serious skin issues and spread disease. That’s why Trifexis makes protecting your dog easy. Packing triple parasite protection into a single, once-a-month, beef-flavored tablet delivers the ultimate convenience in care. No need for greasy topical applications or flea collars. Check the product label for information on application and potential side effects. Dogs must be at least eight weeks old and weigh between 20.1 and 40 lbs. to use this Trifexis formula. You can also find Trifexis available for dogs that weigh as few as 5 lbs. or for dogs weighing up to 120 lbs. Trifexis is only available by prescription. Subscribe to regular doorstep deliveries of Trifexis 6-dose packs so you never miss a monthly treatment. Before starting any heartworm prevention program, it’s important for your veterinarian to test your dog for an existing heartworm infection. At your next visit, tell your veterinarian you want the convenience of triple parasite protection for your dog so you can enjoy peace of mind from the backyard to the dog park. Trifexis is a trademark of Elanco or its affiliates. *Elanco Animal Health, data on file

  • TRIFEXIS (spinosad and milbemycin oxime) is available in five sizes for oral administration to dogs and puppies according to their weight. Each chewable flavored tablet is formulated to provide a minimum spinosad dose of 13.5 mg/lb (30 mg/kg) and a minimum milbemycin oxime dose of 0.2 mg/lb (0.5 mg/kg). Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Spinosyn A and spinosyn D have the chemical compositions C41H65NO10 and C42H67NO10, respectively. Milbemycin oxime is a macrocyclic lactone anthelmintic, containing two major factors, A3 and A4 of milbemycin oxime. The approximate ratio of A3:A4 is 20:80. Milbemycin A4 5-oxime has the chemical composition of C32H45NO7 and milbemycin A3 5-oxime has the chemical composition of C31H43NO7.
  • Tasty, beef-flavored tablet for easy dosing
  • Protecting dogs from parasites for nearly 10 years, 272 million doses distributed (Elanco Animal Health, data on file)
  • Starts killing fleas in 30 minutes and kills 100% of adult fleas within 4 hours
  • Prevents heartworm disease and treats & controls roundworms, hookworms & whipworms
  • Trifexis delivers 5-in-1 protection from heartworms, fleas & 3 more intestinal parasites in dogs 20.1 to 40 lbs.
Weight range 20.1-40 lbs
Pet flea & tick treatment type Flea & Tick Prevention
Product multifunction descriptor 5-in-1 protection
Animal health concern Parasites
Enteral medication form Chewables
Flavor Beef
Parasite type Flea, Tick, Roundworms, Hookworms
Animal lifestage All Lifestages
Maximum pet weight 40 lb
Minimum weight 20.1 lb
Dosage TRIFEXIS is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS).
Protection period 1 Month
Brand Trifexis
Animal dewormer type Anthelmintic
Count per pack 6
Manufacturer Elanco

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